What are Peptides?
Peptides are short chains of amino acids which are actually the building blocks of proteins. Peptides can help the body recover from injury or illness faster, lose weight more efficiently, improve sexual function, decrease inflammation and pain and improve results in the gym.
But Peptides are so much more.
Medical Science already knows of more than 7,000 naturally occurring peptides that have crucial roles in human physiology and performance. They work as hormones, neurotransmitters and growth factors and they serve an amazing variety of maintenance and restorative bodily functions.
Peptides cause a cell-signaling response that can have regulatory and rejuvenating actions on every-day physiology and neuro-endocrine-immune function. Peptides as clinical tools are considered highly selective and efficacious, while also being relatively safe and well tolerated. Did you know that the first peptide discovered was Insulin, way back in the 1920’s?
Peptide therapies for both “on and off label” use, offer exciting therapeutic options for so many medical and health conditions.
Some of these include:
- Increasing human growth hormone levels
- Weight management and appetite control
- Blood glucose and insulin regulation
- Reduced body fat – increased lipolysis
- Cardiovascular support – improved lipids, blood pressure, vascular function
- Improved energy, stamina and decreased fatigue
- Improved sleep patterns
- Improved sexual desire (libido)
- Regulation of other hormones, i.e sex, thyroid, blood sugar, stress
- Improved memory and concentration
- Improved workouts, recovery
- Improve injury recovery
- Improved bone mineralization and density
- Improved immune responses
- Improved inflammatory responses
- Gut health
- Pain control
Peptides We Offer
BPC 157 is a partial sequence of body protection compound (BPC) that was discovered in and isolated from human gastric juice. Experimentally it has been demonstrated to accelerate the healing of many different wounds, including tendon-to-bone healing and it may cause superior healing of damaged ligaments.
In addition, BPC 157 seems to protect organs and to prevent ulcers of the stomach. BPC-157 acts systemically in the digestive tract to combat leaky gut, IBS, cramps, and Crohn’s disease.
This peptide may also ideal for nagging injuries where the tissue needs to be rejuvenated.
Those who suffer from discomfort due to muscle sprains, tears and damage may benefit from treatment with this peptide. It can also help aid skin burns to heal at a faster rate and increase blood flow to damaged tissues.
It appears to work by accelerating the rate of angiogenic repair. Angiogenesis is a key dynamic process for wound healing as it allows the formation of new blood vessels from old ones and is involved in the organization of a microvascular network.
Overall, BPC-157 is a great option to help alleviate joint pain, old injuries, and those looking to improve joint mobility.
Some of BPC-157 potential benefits:
- Improved wound healing (muscle, ligament, tendon, nerve)
- Has been shown to decrease pain in injuries and damaged areas
- Increases growth hormone receptors
- Promotes the outgrowth of tendon fibroblasts, cell survival under stress, and the migration of tendon fibroblasts – leading to improved healing
- Improves digestive function
- May improve blood pressure and nitric oxide production
- Protects and heals inflamed intestinal epithelium (leaky gut)
- It has also been shown to help with Inflammatory Bowel Syndrome (IBS)
Protects the liver from toxic insults (alcohol, antibiotics, etc.) and promotes healing
CJC 1295 is a peptide hormone that is often prescribed by physicians as a growth hormone releasing hormone (GHRH) analog. CJC 1295 has been shown to increase growth hormone (HGH) as well as Insulin Like Growth Factor (IGF-I) secretion and it has been able to do so in very large amounts. CJC 1295 stimulates growth hormone secretion and will keep a steady increase of HGH and IGF-1 with no increase in prolactin, leading to fat loss, and increased protein synthesis thereby promoting growth.
CJC 1295 outperforms the older and outdated GHRH, Sermorelin. The binding life of Sermorelin ranges from 8-12 minutes, whereas the half-life of CJC 1295 extends to 30 minutes. Sermorelin’s efficacy decreases with time as the body increasingly produces anti-bodies to Sermorelin.
Daily injection of CJC 1295, taken just before bedtime, allows the anterior pituitary to follow the natural, nightly, pulsatile release of growth hormone without an increase in appetite stimulation, cortisol, acetylcholine, prolactin, and aldosterone. Typically, you will see CJC compounded with Ipamorelin due to its ability to stimulate GHRH for enhanced results.
CJC 1295 / Ipamorelin may produce the following benefits:
- Increased GH secretion and IFG-1 levels
- Increased lean muscle mass due to the growth of new muscle cells
- Increased bone density
- Improved cognitive function, memory and mental clarity
- Increased cellular repair and regeneration
- Increased fat loss
- Improved workouts and recovery
- Increased energy, strength and stamina
- Deeper more restful sleep
- Decreased joint and muscle pain
- Increased sex drive
- Improved skin tone and texture resulting in fewer wrinkles
- Accelerated wound healing
- Stronger immune system
- Thicker, fuller hair
- Increased bone density and bone strength
- Faster recovery from injuries
- Healthier cardiovascular system
Delta Sleep Inducing Peptide (DSIP) is a well-known neuromodulator and natural sleep generating peptide of 9 amino acids that also has many other physiologic functions. It is typically found in the brain and easily passes the blood-brain barrier. It is mainly prescribed for the treatment of insomnia, pain diseases, alcohol and opioid withdrawal, stress related symptoms, low testosterone, and even sometimes as an antioxidant and antioncogenic protein.
It has been discovered and heavily studied for over 40 years, yet the mechanism of action is still complex and not well categorized. The results of studies of DSIP and its analogues since its discovery enable one to state with confidence that DSIP is a unique member of the family of peptide neuromodulators. It exhibits a pronounced stress protective action and decreases stress-induced metabolic and functional disorders in human and animal organisms exposed to the stresses of different natures. The effects of the peptides are accomplished through the modulating action on central regulatory processes, owing to the systemic antioxidant action, the modulating influence on the activity of GABAergic, glutamatergic, and other neuronal systems, on the expression of early response genes in brain structures, and on the activity of biosynthetic and proteolytic processes
Since the discovery of DSIP a number of studies have been undertaken to test the theory that DSIP may be the primary substance responsible for generating sleep. It is reported to increase the ‘pressure to sleep’ in human subjects who have been injected with small doses and this, together with its ability to induce delta-wave sleep, led to its consideration as a treatment for insomnia. A number of studies have examined this.
DSIP is more accurately described as a sleep-promoting substance rather than a sedative. There is a modulating effect on sleep and wake functions with a greater activity in circumstances where sleep is disturbed. There are minimal effects in healthy subjects who are not suffering from sleep disturbance. DSIP is not a night sedation drug which needs to be given just before retiring. A dose of DSIP given during the course of the day will promote improved sleep on the next night and for several nights thereafter.
It has been used for the treatment of poor sleep, pain conditions, stress-related symptoms, low testosterone (via stimulation of LH), and even sometimes as an antioxidant and anti-cancer protein. It exhibits a pronounced stress protective action and decreases stress-induced metabolic and functional disorders in human and animal organisms exposed to a variety of stresses. It has also been shown in research to improve hormone levels and physical performance.
Potential benefits of DSIP:
- Can restore disturbed sleep patterns
- Can modulate cortisol production
- Can reduce persistent/chronic pain
GHK-Cu is a naturally occurring copper complex that was first identified in human plasma. It has recently been found in multiple locations such as saliva and urine. Copper peptides are small, naturally occurring protein fragments that have high affinity for copper ions, which are critical to normal body function. GHK-Cu has a variety of roles in the human body including, promoting activation of wound healing, attracting immune cells, having anti-oxidant and anti-inflammatory effects, stimulating collagen and glycosaminoglycan synthesis in skin fibroblasts, and promoting blood vessel growth.
Evidence has shown that it acts as a feedback signal that is generated after tissue injury. It seems to act as a potent protector of tissue, and it is an anti-inflammatory agent that controls the oxidative damage that occurs after tissue injury. Further, it then plays a big role in signaling tissue remodeling which removes damaged/scarred tissue and generates new, healthy tissue.
The concentration of GHK-Cu in the body decreases with age and as a result its protective and healing effects decline as well. Thus, there is an increase in inflammation, cancerous activity, and tissue destruction. In plasma, the level of GHK-Cu drops by nearly 75% between the ages of 25 and 70.
GHK-Cu plays an important role in skin biology and it is widely used in cosmetics as a reparative and age management ingredient. GHK stimulates both synthesis and breakdown of structural tissues and it modulates the activity of damaging inflammation and inflammatory factors. It stimulates collagen, dermatan sulfate, chondroitin sulfate, and proteoglycans. It also restores vitality to fibroblasts (reparative cells of the body) after radiation therapy. The molecule accelerates wound-healing of the skin, hair follicles, gastrointestinal tract, and boney tissue. In cosmetic products, it has been found to tighten loose skin and improve elasticity, skin density, and firmness, reduce fine lines and wrinkles, reduce photodamage, and hyperpigmentation, and increase keratinocyte proliferation.
Potential benefits of GHK-Cu:
- Increase hair growth and thickness, enlarge hair follicle size
- Tighten loose skin and reverse thinning of aged skin
- Repair protective skin barrier proteins
- Improve skin firmness, elasticity, and clarity
- Reduce fine lines, depth of wrinkles, and improve structure of aged skin
- Smooth rough skin
- Reduce photodamage, mottled hyperpigmentation, skin spots and lesions
- Improve overall skin appearance
- Stimulate wound healing
- Protect skin cells from UV radiation
- Reduce inflammation and free radical damage
Melanotan II (MT2) is a peptide which stimulates the melanocytes to induce skin tanning. Melanocyte Stimulating Hormones (MSH) are a class of peptide hormones produced in the pituitary gland that stimulate melanocytes (pigment producing cells) in the skin and hair to produce and release melanin which leads to darker skin and hair.
Melanin is the skin pigment produced that protects our skin from the sun’s ultraviolet (UV) radiation and damage. It’s like our body is producing its own natural sunscreen. Pale skin with low levels of melanin make the skin highly susceptible to DNA damage with excess sun exposure. This lack of melanin and its protection against UV radiation means that those individuals with fair skin have a propensity to burn and risk more DNA damage. It also means that these individuals must take great care to make sure that they tan safely without burning.
To get a safe tan, we need to stimulate the melanocyte stimulating hormone that is responsible for increasing melanin production. Scientists discovered the use of a “tanning peptide” when investigating possible ways to treat skin cancer. They figured that by inducing the body’s natural pigmentary system through the process of melanogenesis, a protective tan could be produced before UV exposure, thereby reducing the potential for skin damage. With just a little UV exposure, the release of a- Melanocyte Stimulating Hormone (MSH) stimulates a natural increase in the production of melanin from the melanocytes in the skin. Use of the tanning peptide provides more MSH which results in more melanin being produced and greater tanning potential (skin pigmentation) regardless of your skin type.
Potential benefits of a Melanocyte Stimulating Hormone:
- The ability to achieve a darker tan with less exposure to UV radiation
- Possible reduction in the risk of Melanoma (skin cancer)
- A possible reduction in the incidence of sun-damaged skin
- Fair skin individuals have the ability to develop a tan through the use of the Melanotan II peptide.
- It can lead to reduction in body fat
- No sunburn, No tan lines
- No sunless tanning streaks or fake tan removal
- It can increase libido
(Interesting note: During clinical trials for its use as a tanning agent, Melanotan II was found to be a potent stimulator of male erections. It has also been shown to increase female sexual desire in patients with sexual arousal disorder and it has now been developed into another unique peptide called Bremelanotide or PT-141).
MK-677 is a long active orally bioactive agonist of the GHS-R1a. As such, binds to the same receptors that Ipamorelin also stimulate. Also called Ibutamoren, it has shown to cause a predictable rise in Insulin Like Growth Factor (IGF-1) but unlike other Growth Hormone secretagogues, it doesn’t help to decrease adipose tissue. It has been shown to increase lean muscle mass and might be a good candidate for sarcopenic patients with low bone mineral density. In order to reduce the negative effect of somatostatin, MK-677 is best taken on an empty stomach with no insulin in the system.
As far as HGH secretagogues go, MK-677 is advantageous due to it oral administration as opposed to injection for the others. So, compliance is easier.
What are some potential benefits of MK-677:
- Increased lean muscle mass due to growth of new muscle cells
- Improved workouts and recovery
- Reduced body fat
- Increased energy, strength and stamina
- Deeper more restful sleep
- Decreased joint and muscle pain
- Increased sex drive
- Improved skin tone and texture resulting in less wrinkles
- Improved mental clarity
- Accelerated wound healing
Bremelanotide (PT-141) was developed from the peptide hormone Melanotan II. In initial testing, Melanotan II induced darkening of skin pigment, but additionally caused sexual arousal and spontaneous erections as unexpected side effects in nine out of the ten original male volunteer test subjects. Further testing in animals showed Bremelanotide to induce lordosis (a sexual mating behavior) and subsequently tested for its effect in humans. Although, most of the research has been targeted to women with female sexual dysfunction and it is effective medication in treating sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). Unlike Viagra and other related medications, it does not act upon the vascular system, but directly increases sexual desire via the nervous system.
It is estimated that 43% of women (30 million is the US) suffer from sexual dysfunction and 30 million men suffer from ED, with incidence increasing 2-3 fold between ages 40-70. Bremelanotide currently has no contraindications and is 80% effective in people who don’t respond to Viagra or Cialis.
Both men and women might benefit from Bremelanotide or PT-141. Those that experience
- Lack of desire or lack of receptivity to sexual activity (both men and women)
- Inability to become aroused (both men and women)
- Decreased sensation (women)
- Pain with intercourse (women)
- Inability to achieve an orgasm (both men and women)
- Emotional issues such as embarrassment, shame, anxiety, and a reduced interest in sex (women)
- Erectile Dysfunction (men)
Thymosin Alpha-1 (TA-1) is a peptide or very small protein that is responsible for restoring immune function, particularly cell mediated immune function. Recent studies suggest that the Thymosin Alpha-1 molecule has a major immunoregulatory role.
The drug is in Phase III trials for the treatment of hepatitis C and in Phase II trials for hepatitis B. Additional possible indications are malignant melanoma, hepatocellular carcinoma, drug-resistant tuberculosis, and Di George’s syndrome as well as any chronic cancer or viral disease. Some physicians are using thymosin for chronic fatigue and Lyme disease as well.
It is already approved in more than 37 countries for the treatment of hepatitis B, hepatitis C, and as an adjunct to chemotherapy and various vaccines. TA-1 has been found to have a profound effect on the immune system and is the active ingredient in the immune modulating drug, Zadaxin®. Zadaxin® is used to treat hepatitis B and C and has been studied extensively for its ability to support an immune system that has been suppressed by chemotherapy in cancer patients. Additional possible indications are malignant melanoma, hepatocellular carcinoma, drug-resistant tuberculosis, chronic fatigue and Di George's syndrome as well as any chronic cancer or viral disease.
In addition to its use in the treatment of Hepatitis, AIDS, and cancer, TA-1 has shown great promise in the treatment of Lyme disease. This is unsurprising when one considers the large role the immune system plays in combating the disease.
TA-1 assists the immune system in the location and eradication of the Lyme bacteria and infected cells, while helping to prevent oxidative damage, thereby decreasing inflammation and enabling a better quality of life throughout treatment.
Potential benefits of Thymosin Alpha-1
- Enhances the function of certain immune cells called T and dendritic cells
- Effective for acute and chronic infections
- Help eradicate the unhealthy cells and stop the infection or cancer growth
- Exhibits antibacterial, antiviral and antifungal properties
- Suppresses tumor growth
- Increases vaccine effectiveness
- Protects against oxidative damage